Beneficial Pharmacokinetic Drug Interactions

Beneficial Pharmacokinetic Drug Interactions

A drug interaction occurs when the usual effects of a drug are enhanced or diminished by another drug being taken by the patient. In most cases, these interactions are unintentional and come to the attention of clinicians due to a therapeutic failure or adverse event that is undesirable. Polypharmacy and drug interactions are common particularly among seniors. A survey of elderly individuals li...

Beneficial Drug Interactions

4 The long-term success of an antiretroviral regimen depends on maintaining inhibitory concentrations of active drug at the site of HIV replication sufficient to suppress viral load and prevent viral mutation and resistance. Although HIV inhibitory concentrations can be identified for antiretroviral drugs, there are persistent issues surrounding the use of drug blood concentrations to guide tre...

Pharmacokinetic Drug Interactions of Azoles

Pharmacokinetic drug interactions of macrolides.

The macrolide antibiotics include natural members, prodrugs and semisynthetic derivatives. These drugs are indicated in a variety of infections and are often combined with other drug therapies, thus creating the potential for pharmacokinetic interactions. Macrolides can both inhibit drug metabolism in the liver by complex formation and inactivation of microsomal drug oxidising enzymes and also ...

Evaluation of Pharmacokinetic Drug Interactions in Prescriptions of Intensive Care Unit (ICU) in a Teaching Hospital

Concomitant use of several drugs by ICU( Intensive Care Unit) patients is often unavoidable. In these patients, pharmacokinetic drug interactions are very likely. The current study was designed to evaluate these interactions in patients hospitalized in an ICU of a teaching hospital in Tehran, Iran. A questionnaire was designed and used to collect study data. The study was done in the ICU of a t...